Exploring Inflammation of Infection of Chicken Embryos before 12 days of embryonic development: A Promising Experimental Model
Publicado: 17/07/2025 - 12:07
Última modificação: 17/07/2025 - 12:07
Convidamos a todos para a Defesa da Tese de Doutorado da discente do nosso programa, Simone Sommerfeld.
A defesa pública ocorrerá no dia 30/07/2025 às 14h00, no Anfiteatro do Hospital Veterinário, Campus Umuarama.
Será apresentado o trabalho com título: Exploring Inflammation of Infection of Chicken Embryos before 12 days of embryonic development: A Promising Experimental Model
Abstract: The chicken embryo (CE) has emerged as a valuable in vivo model for
investigating immune development, infection, and inflammation. This review outlines the
biological and practical advantages of the CE model, emphasizing its phylogenetic
proximity to mammals, well-characterized development, and accessibility for
experimental manipulation. The ontogeny of the immune system is discussed, including
the formation of primary and secondary lymphoid organs and the early appearance of
innate and adaptive immune responses. Special attention is given to the suitability of the
CE for modeling inflammatory responses, particularly in studies using live pathogens
such as Salmonella Pullorum. Several studies have successfully employed the CE to
assess bacterial virulence and host–pathogen interactions, demonstrating its relevance for
infection biology. Furthermore, we highlight ethical considerations related to animal
welfare, noting that the use of embryos before the development of nociception aligns with
the principles of the 3Rs. Together, these findings support the CE as a robust and ethically
responsible model for studying early host responses to infection and inflammation.